Chemical Biology of Nucleic Acid-binding Proteins

Abstract

Nucleic acid-binding proteins play crucial roles in all aspects of nucleic acid metabolism, including DNA replication, transcription, and repair. In this presentation, the speaker will discuss his recent studies that use mass spectrometry-based quantitative proteomic approaches to uncover novel cellular proteins that recognize guanine quadruplex DNA and modified nucleosides in DNA/RNA. The functional characterization of several selected nucleic acid-recognition proteins, including their roles in long-range DNA looping, DNA repair, and nucleotide repeat expansion diseases, will also be presented. Through this presentation, the speaker hopes to illustrate that chemical biology constitutes a powerful approach for revealing novel functions of nucleic acid-binding proteins.

About the Speaker

Prof. WANG Yinsheng received his PhD from Washington University in St. Louis after obtaining his BS and MS degrees from Shandong University and the Dalian Institute of Chemical Physics, Chinese Academy of Sciences, respectively.  He joined the faculty of the University of California, Riverside in 2001, where he is now a Distinguished Professor and the Donald T. Sawyer Endowed Founder's Chair in Chemistry. His current research involves the use of mass spectrometry, synthetic organic chemistry, molecular biology, genetic and genomic tools for assessing the occurrence, repair and biological consequences of DNA damage. His ongoing research also includes functional characterizations of modified nucleosides in RNA and their implications in human diseases.  Prof. Wang has trained (or is in the process of training) of over 90 PhD students and postdoctoral fellows, and he has co-authored over 350 research articles. He has served as an Associate Editor for Chemical Research in Toxicology since 2018.

For Attendees' Attention

Seating is on a first come, first served basis.